Key matchups -- Colts QB Andrew Luck vs. Texans pass defense. Luck hasn’t thrown for huge numbers this season (1,574 yards, 10 touchdowns) but he has only had three passes picked off. He is completing nearly 61 percent of his throws. Houston, meanwhile, has limited opposing quarterbacks to 58.5 percent completion percentage and have recorded 16 sacks.
Texans WRs Andre Johnson/DeAndre Hopkins vs. Colts CBs. The Indianapolis secondary did a nice job of defending Denver’s potent passing game two weeks ago. But CB Greg Toler has been nursing a groin injury, which means that backup Cassius Vaughn might get the call as a replacement. CB Vontae Davis was dinged up against the Broncos but should be good to go this week. Johnson (48 catches for 584 yards) and Hopkins (28-416, 2 TDs) will be formidable targets.